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Peripheral neuropathy in diabetic patients on metformin is often due to two factors: diabetes itself and B12 deficiency

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Phagocytic cells, through oxidative stress, are involved in tissue and organ damage [20]

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Both semaglutide (a GLP-1 receptor agonist) and tirzepatide (which targets both GLP-1 and GIP receptors) work by regulating appetite, improving blood sugar control, and helping the body feel fuller with less food

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This is classic metabolic syndrome

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