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It has been reported that GSH is reduced by the following side reactions under neutral conditions (Methods in Enzymology, 1985, 113, 548)

In the phase 2 dose-finding trial involving 706 participants, nausea rates varied dramatically by dose

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Cardiolipin can be oxidized by ROS or by the cardiolipincytochrome c complex ( c from cardiolipin might also be triggered by increased cytosolic calcium, which weakens the electrostatic interaction between cytochrome c and cardiolipin and further generates ROS via MPT