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When gain-of-function LRRK2 mutants are anchored to mitochondria, it phosphorylates and traps Rab10 nearby (Gomez et al., 2019), causing decreased interaction of Rab10 with OPTN (optineurin), which is an autophagy receptor, therefore impairing mitophagy (Wauters et al., 2020)
Active malignancy: use with caution HGF/c-Met promotes cellular growth Pregnancy and breastfeeding: insufficient data
Often explored by individuals aiming to support fat loss protocols alongside proper nutrition and training
5-Amino-1MQ Side Effects and Safety Questions Because human safety data is limited, the side effect profile of 5-Amino-1MQ is not fully established
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