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32,33 Under physiological conditions, besides the paracrine secretion pathway in the gastrointestinal tract, most endogenous GLP-1 in circulation is locally deactivated by DPP-4 and the liver, 34 making it difficult to directly enter the CNS through the blood-brain barrier
Issues with safety, competition, or patent expiration can mean the company takes a bigger hit
Aqua (Water), Paraffinum Liquidum, Niacinamide, Butyrospermum Parkii Butter, Polysorbate 60, Propylene Glycol, Glycerin, Cetyl Alcohol, Octyldodecanol, Dimethicone, Glyceryl Stearate, PEG-100 Stearate, Parfum (Fragrance), Glutathione, Ascorbyl Tetraisopalmitate, Cera Microcristallina, Paraffin, Sodium Polyacrylate, Carbomer, Citric Acid, Chlorphenesin, O-Cymen-5-ol, Alpha-Isomethyl Ionone, Benzyl Alcohol
doi: 10.1016/j.cell.2012.03.042 18 YanHFZouTTuoQZXuSLiHBelaidiAAet al
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