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Immunofluorescent (IF) staining of K1 cells was performed and revealed a significant increase in TfR1 protein expression compared to DMSO-treated control cells (RSL3 94.7% vs

PMC 4189588

developed a novel hypoxia-activated combination nanomedicine that targets hypoxic tumors through hypoxia-sensitive block copolymers and photothermal/photodynamic therapy (PTT/PDT), efficiently delivering drugs and achieving synergistic anticancer effects of chemotherapy and PDT/PTT, completely eliminating advanced breast cancer, including hypoxic and metastatic tumors, stimulating a systemic antitumor immune response, and significantly improving survival rates, showing important clinical application potential [500]