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In ALD, ethanol metabolism via hepatocyte CYP2E1 generates excess ROS and acetaldehyde, inducing endoplasmic reticulum stress and mitochondrial dysfunction [365]
Recent research has shown that epithelial cells play a role in inflammation (39)
However, the complex composition of gut microbiota means that the gut microbiota that contributes most to CVDs and the specific mechanism of TMAO are not fully understood
Conversely, when estrogen levels dropwhich happens right before and during menstruationantioxidant activity may also dip
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