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Catalase is a crucial antioxidant enzyme that plays a vital role in protecting cells against oxidative damage 21,22
the peptide is used in conjunction with a PDE-5 inhibitor
Due to cardiomyocytes requiring massive energy demands, they are rich in mitochondria standing out from the rest of the cell type [15, 16], which makes them very sensitive to oxidative stress damage
Thus, organoids have provided insights into the complex pathophysiology of MELAS, indicating that neurodevelopmental defects are intrinsic to MELAS
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