A 2003 study demonstrated average telomere elongation of 33.3% in human fetal fibroblast cultures, with treated cells surpassing the Hayflick replicative limit (3)
[4] Based on animal research, it is thought that the increased methylmalonyl-CoA hydrolyzes to form methylmalonate (methylmalonic acid), a neurotoxic dicarboxylic acid, causing neurological deterioration
Nascobal may be prescribed for individuals with: Pernicious anemia Post-gastric bypass or GI surgery Chronic atrophic gastritis B12 deficiency due to Crohns disease or other GI conditions Long-term use of metformin or acid-reducing medications Vegetarian or vegan diet with inadequate B12 intake It is not intended for use in those with nasal congestion or damage to nasal tissue unless otherwise advised by a healthcare provider
Kirchmair R, Marksteiner J, Troger J, Mahata SK, Mahata M, Donnerer J, Amann R, Fischer-Colbrie R, Winkler H, Saria A