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Patients with severe, longstanding deficiency typically require longer recovery periods, with haematological improvement occurring over weeks and neurological recovery potentially taking months
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However, Tirzepatide and Semaglutide are more widely available and have longer-standing clinical data
Another approach, which seems promising for future treatment of NAFLD, is the combination of GLP-1 and glucagon, since the latter may potentiate incretin-mediated weight loss and increase lipid utilization and FFA oxidation in the liver
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