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In SURPASS-AP trial insulin-naive diabetic patients not adequately controlled on therapy with metformin (with or without a sulphonylurea) in Australia, India, China and South Korea, were randomized to TZP 5 mg, 10 mg or 15 mg or insulin glargine
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Improving drug bioavailability begins with a thorough evaluation of the APIs physical and chemical properties in relation to solubilization in the dose, but more importantly its dissolution in vivo at the site of absorption
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