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Clinical Studies and Evidence SUSTAIN-6 Trial (Cardiovascular Outcomes) Published in the New England Journal of Medicine (2016), the SUSTAIN-6 trial demonstrated that Semaglutide significantly reduced the risk of major adverse cardiovascular events (MACE) cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke by 26% compared to placebo in patients with Type 2 diabetes and high cardiovascular risk

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Warning signs include taking higher doses than prescribed, using someone elses medication, or feeling unable to function or eat normally without the drug