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Interestingly, both estradiol and leptin receptors colocalize in kisspeptinergic neurons, which are considered to be the link between nutrition (metabolism) and reproduction (ovulatory function) (151)

This is something to keep in mind when you consider drinking alcohol

Yes, common side effects like nausea, fatigue, or GI discomfort might reduce interest in sex temporarily, especially during dose escalation

By contrast, 7-hydroxymitragynine (7-OH), while also labeled a partial agonist, is highly potent at the same receptors and produces dose-dependent respiratory depression and dependence signals in animal studies