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Read codes and SNOMED-CT terms are used to code clinical data such as diagnoses and procedures, and prescriptions are recorded using drug codes linked to the British National Formulary.21 More than 90% of patients in the CPRD are linkable to other datasets.2223 The HES APC database contains hospital admission records from English National Health Service hospitals and includes information such as admission and discharge dates, diagnoses (recorded using ICD-10 (international classification of diseases, 10th revision) codes), specialists seen, and procedures undertaken for all linked patients.23 The ONS database is a vital statistics database that contains data on registered deaths in the UK, including the official date and causes of death.23 Study population We used a prevalent new-user design,24 a design that emulates a randomised controlled trial,25 to investigate the effect of the GLP-1 receptor agonist-SGLT-2 inhibitor combination on cardiorenal outcomes compared with either drug class alone or with other antihyperglycaemic drugs

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