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Free Radical Biology and Medicine, 39, 34554

Increasing muscle derived IGF-1 was found protective in mouse models of ALS 11 , and delivering IGF-1 in the CNS also led to increased survival 12,13

And protein kinase A phosphorylates hormone-sensitive lipase, the enzyme that physically breaks triglycerides apart into free fatty acids and glycerol

Such activity has been associated with altered lipid and carbohydrate turnover, making IGF-1 LR3 a subject of interest in studies addressing cellular metabolism