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456,457 Metformin mediates improved insulin sensitivity by increasing insulin receptor tyrosine kinase activity, enhancing glycogen synthesis, and increasing the recruitment and activity of the glucose transporter GLUT4
The latter finding may suggest that the Glp1r -independent inhibitory effects of GLP-1(7-36) on glucagon secretion are actually mediated by the breakdown product GLP-1(9-36)
Based on studies of branded medications in non-diabetics with obesity, or with overweight plus a weight-related condition, with diet and exercise
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