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The inhibition of serine and glycine bidirectional conversion by sertraline prior irradiation reduces the pool of nucleotides, as we previously observed, and concurrent and post-treatment with sertraline might hinder the synthesis of the antioxidant GSH and NADPH production, which exposes cancer cells to the accumulation of endogenous ROS and radiation-induced ROS causing severe oxidative stress [70]

Reduced GSH and oxidized GSSG In the body, glutathione mainly exists in two interconvertible forms: reduced glutathione (GSH) and oxidized glutathione (GSSG), and the balance between these forms reflects cellular redox status

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