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10.34172/mejdd.2022.278 54 SchmidtH
The program rested in part on the expectation that improving biomarkers and engaging the target would track with clinical benefit, a logic laid out in the published rationale and design of the trials
Rats receiving brainstem-hypothalamic transection do not have a reduction in food intake in response to peripherally administered GLP-1 which suggests that the brainstem plays a critical role in communicating peripheral satiety signals to higher brain centers (Abbott et al., 2011)
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