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Remarkably, malic enzyme 1 (ME1), which yields pyruvate from malate and converts NADP + to reduced nicotinamide adenine dinucleotide phosphate (NADPH), might reduce the accumulation of ROS and redox-active iron, hence resisting ferroptosis induced by inhibition of SLC7A11 [43]

The comparison of their accumulation patterns in resistance, susceptible, and mock responses revealed a marked GST accumulation during resistance responses pointing to the role of GST as a positive regulator of resistance (Bai et al., External factors, such as light have a strong influence on plant defense reactions and disease resistance

It was originally studied for its gastroprotective effects , with researchers exploring its potential to heal stomach ulcers