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Given these potential mechanisms, this study was designed to test the hypothesis that DIO mice restored to the weight and adiposity of LD controls through NNMTi treatment and LD switch 13 have a similar microbiome profile to mice continuously maintained on LD

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The pediatric indication requires dedicated clinical trials demonstrating safety and efficacy in that age group, which Wegovy has, and Ozempic does not, says Omodamola Aje, MD , a board-certified endocrinologist