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The factor responsible turned out to be a small copper-binding tripeptide whose endogenous concentration declines with age from roughly 200 ng/mL at age 20 to 80 ng/mL at age 60. The 50-year research arc that followed makes GHK-Cu one of the most thoroughly characterized small peptides in the literature
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In a Drosophila melanogaster model of PD, spermidine reduced brain function decline and decreased accumulated -synuclein by restoring autophagy (Reference Bttner, Broeskamp and Sommer77)
For the day 1 clinical measure scores (MADRS, QIDSSR, M3VAS, SHAPS, TEPS-A and TEPS-C), linear mixed-effects models were also used with condition (placebo and naltrexone), time (preinfusion and day 1 postinfusion), visit (visit 1 and visit 2) and the interaction between condition and time as fixed effects
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