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What You May Notice Over Time Weeks 1 to 2: You may start to feel full sooner and think about food less often Weeks 2 to 4: Cravings may feel less intense and meals may start to feel easier to manage Weeks 4 to 8: Some people begin to notice gradual weight loss, along with steadier energy or better control of eating After 8 weeks: Weight loss may become more noticeable as healthy habits and treatment start working together

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10.1159/000192953 46 PugazhenthiS.NesterovaA.SableC.HeidenreichK

Effects of tirzepatide on body weight and cardiometabolic risk factors in people with overweight or obesity: a post hoc analysis of the SURPASS clinical trial program