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In comparison to the WT, assays evaluating interactions with HD11 chicken macrophages revealed a substantial impairment in the adhesion and invasion capabilities of the GR mutant strain (Figures 1F and G)

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Ferroptotic cells exhibit distinctive mitochondrial morphology, characterized by shrinkage, increased electron density, reduced cristae, and outer membrane rupture compared to normal cells ( 2 ) ( Mitochondrial damage can trigger mitochondrial DNA (mtDNA) release, activating the cGAS-STING1 pathway and potentially contributing to ferroptosis, as observed with inducers like zalcitabine (116)

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