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Mice that lack an organised synovial lining layer due to the deficiency of cadherin-11 are indeed resistant to the development of arthritis, demonstrating a causal role of fibroblasts in the disease ( + THY1 + cells are mainly mediators of inflammation, the destruction of joint tissues is mostly mediated by FAP + THY1 - fibroblasts ( The driving role of fibroblasts in cancer is also well studied
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Both are medications primarily used to treat type 2 diabetes and obesity
Rather than binding to a single metabolic receptor, this research peptide is engineered to interact with three distinct receptor targets involved in glucose and lipid metabolism: the glucagon-like peptide-1 (GLP-1) receptor, the glucose-dependent insulinotropic polypeptide (GIP) receptor, and the glucagon receptor
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