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A 2012 analysis by Pickart and Margolina identified that GHK-Cu modulates the expression of over 4,000 human genes approximately one-third of all genes with a known biological function

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This suggests that long-term maintenance on an LD rich in carbohydrates may confound some of the microbiome differences commonly reported between mice on HFDs and those on lean control diets which contain fewer carbohydrates