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Synthetic hydrogels (e.g., polyethylene glycol [PEG], poly(vinyl alcohol) [PVA], and polyacrylamide-based systems) provide precise control over composition, degradation rate, and cargo release, enabling reproducible and tunable therapeutic performance [82, 83]
Zhou Z et al
Simultaneously, the preservation of SAM levels maintains cellular capacity for critical methylation reactions including histone modifications, DNA methylation, and protein methylation that regulate gene expression and protein function
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