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13 Hyperuricemia is known to stimulate the renin-angiotensin system and impair endothelial nitric oxide release, which collectively lead to renal vasoconstriction and increased blood pressure
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Your doctor will typically: Check blood tests (potassium, kidney function) before starting and periodically during treatment Monitor your blood pressure regularly Adjust either medications dose based on your response and any side effects Possibly increase monitoring frequency if you have heart failure, kidney disease, or take other medications affecting potassium Take home message Mounjaro and spironolactone can be taken together safely, but this combination requires appropriate monitoring of potassium levels, kidney function, and blood pressure
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