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Mucin Layer Regulation First described by Muriel Derrien and colleagues (2004, Int J Syst Evol Microbiol ), Akkermansia muciniphila resides in the mucus layer
This leads to an increase in whole body radical burden, and increased oxidative damage to cell membranes
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However, after advanced chemical modifications and the development of targeted delivery systems, the first siRNA drug approved by the Food and Drug Administration (FDA) in 2018 reignited interest in NADs
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