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The theoretical concern about angiogenesis-driven tumor promotion persists despite absence of evidence specifically because the question has not been adequately studied in humans over meaningful timeframes
From Rat Studies to Human Extrapolation From rat studies, the remarkably consistent effective dose range of 0.0045 mg/lb to 0.0000045 mg/lb intraperitoneally (a 1000-fold range showing similar efficacy) worked across depression, anxiety, Parkinsons, stroke, schizophrenia, and seizure models
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