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For the analysis involving patients with both T2DM and obesity, we included those who were prescribed GLP-1RAs or control medications within one year following their diagnosis of both T2DM and obesity, between April 2013 and April 2019
These medicines are licensed for different indications some specifically for type 2 diabetes (e.g., Ozempic, Trulicity), while others are licensed for weight management (e.g., Wegovy, Saxenda) in line with NICE guidance
[39] It completed phase III trials globally in 2021
However, in the presence of hypoxia and excess hemin exposure along with supraphysiological concentrations of cystine, we readily detected the ability of DMF in contributing cysteine availability (Fig
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