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The thyroid warning is a boxed warning based on C-cell tumors seen in rodents
Sivamani 2010)
The peptide's modified structure allows it to bypass typical protein binding that would normally limit its effectiveness
According to the classic two-hits model, the increased insulin resistance, secondary to metabolic syndrome, determines an excessive lipid accumulation in healthy hepatocytes (first hit), mainly through an increased mobilization of free fatty acids from visceral adipose tissue to the liver
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