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However, our included studies intervening with a dosage higher than 2000mg/d seemed to show more benefit to patients [9,10], while one subgroup [9] with 1500mg/d showed less reduction in VAS (p value not provided)

Scientists at the University of California San Diego found not only that fungi thrived in the intestines of mice exposed to high doses of alcohol, but that the inflammation created by the spawning fungi sped up the onset and progression of alcohol-related liver disease (Nonalcoholic fatty liver disease affects up to a third of Americans, taking a toll on our collective health

This is not marketing speculation

Assuming an average 1520% body weight reduction, and that the majority of excess adipose carbon is oxidised within 1218 months, the theoretical CO liberation would likely be distributed over a relatively short temporal window