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Their potential therapeutic relevance in disease-specific contexts is discussed based on preclinical and observational data and should be regarded as hypothesis-generating rather than evidence of clinical efficacy

Randomized controlled trials The double-blind, placebo-controlled Nutritional Prevention of Cancer (NPC) study in 1,312 older adults with a history of nonmelanoma skin cancer found that supplementation with 200 g/day of selenium-enriched yeast (selenized yeast) for an average of 7.4 years resulted in a 52% decrease in prostate cancer incidence in men (81)

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