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Acknowledgements This paper is dedicated to the memory of Beatriz Tavares Costa-Carvalho

Patients on this protocol who also use metabolic support agents like Metformin should note that both agents activate AMPK, and physician oversight is warranted to avoid compounding effects on blood glucose that could theoretically cause hypoglycemia in susceptible individuals, though this has not been reported clinically with MOTS-c at standard doses

Freezing reconstituted KLOW is one of the few errors that cannot be reversed or mitigated