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Both the thioredoxin (Trx) and GSH-dependent glutaredoxin (Grx) antioxidant systems have been found to reduce methionine sulfoxide reductases in vitro and/or in vivo (see Figure 2 ) (28)

Nevertheless, clinicians should continue following established precautions and reviewing patient history before initiating therapy

First: a medical provider determines during the initial consultation that you are not medically eligible for treatment based on established medical guidelines