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Tschop recounted his research with DiMarchi and that of others while he accepted the 2023 Banting Medal for Scientific Achievement at the 2023 American Diabetes Association Scientific Sessions.5 The FDA approved the first GLP-1 agonist, twice-a-day Byetta (exenatide), in 2005.1 Since then, several newer and more powerful medications in the GLP-1 agonist class, such as liraglutide and semaglutide, have received FDA approval for type 2 diabetes, with a higher dose of semaglutide FDA approved for weight loss.2 In mid-2022, the first dual agonist, tirzepetide (a combination of a GLP-1 agonist and a GIP), was FDA approved for type 2 diabetes

The brain is responsible for regulating how much is eaten and how many calories are burned throughout the day, but in obesity, this balance is disrupted, causing weight gain

There is little to no data or direct research on whether microdosing GLP-1s leads to meaningful weight loss or long-term weight management, Dr

Each mouse was individually placed in the arena, and both distance traveled and time spent at rest were recorded over a 10-min period