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Further, there is no indication of medical efficacy of these unregistered products with GLP-1 claims, in particular for weight-loss. The TGA urges consumer caution when purchasing medicines from unknown overseas websites, suggesting these products could be fake, contain incorrect or undisclosed and harmful ingredients, and may not meet the same standards of quality, safety and efficacy as those approved by the TGA for supply in Australia

SCFAs promote the production of 5-Hydroxytryptamine affecting gastrointestinal motility, enterochromaffin (EC) cells sense SCFAs and produce 5-HT, which promotes gastrointestinal motility through activation of 5-HT4 expressed on enteric neuron receptors to promote gastrointestinal motility (81)

doi:10.1007/bf00710420

& Zoeller, R