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Growth hormone secretagogue peptides: Mechanism of action and clinical potential

Our study revealed disproportionate rates of discontinuation among various GLP-1RAs, with semaglutide being discontinued more frequently compared to liraglutide and other agents within 6 months of starting the first-line therapy

Pancreatitis and pancreatic cancer Despite the current guidelines against individuals with a history of pancreatic cancer or pre-existing pancreatic conditions, theres no strong evidence that semaglutide, or other GLP-1 medications, increases the risk of pancreatitis, pancreatic cancer or other pancreas-related conditions

Mechanisms of action Osmolyte increasing cell volume and a methyl donar