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A phase 2 study evaluating the effects of 24 weeks of IMM-124e in patients with biopsy-proven MASH showed a reduction in AST and ALT but no change in hepatic fat content (NCT02316717)
Impairment of short-chain fatty acid (SCFA) and l-isoleucine biosynthesis in gut microbiome persists beyond 30 days after recovery from COVID-19, which could contribute to persistent leaky gut and dysbiosis in PASC patients 237,238
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Exogenously, they arise from exposure to environmental factors like ultraviolet (UV) radiation, pollution, tobacco smoke, and industrial chemicals [3]
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