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Anderson HL, Brodsky IE, Mangalmurti NS
55,56,57 Recently, the first gene therapy based on clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 technology has been approved for marketing, 58 resulting in revolutionary changes in NADs development
A variety of cellular stresses, including DNA damage can cause the induction of cellular senescence, which represents a multifaceted and highly heterogeneous cellular state characterized by irreversible growth arrest and importantly the secretion of a multitude of factors, including proteases and chemokines 2
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