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Many people choose Friday or Saturday evenings so they can rest over the weekend if side effects occur
Indications: Overactive bladder Common symptoms include urgency, urinary incontinence, and increased urinary frequency Side Effects: dry mouth constipation QT prolongation urinary tract infection worsening of myasthenia gravis aggravation of decreased GI motility in patients with autonomic neuropathy WARNINGS: angioedema of the face, lips tongue and/or larynx has been reported CNS Effects: agitation, confusion, hallucinations, abnormal behavior & memory impairment in patients taking 5 mg oxybutynin for more than 3 years compared to no use (Thomas & Walters, 2021): increased risk of dementia (adjusted hazard ratio 1.54) increased risk for Alzheimers disease (adjusted HR 1.63) Pharmacokinetics: taken orally by tablet, 5 or 10 mg once daily metabolized by CYP3A4 half life 13 hrs Notes: the estimated Walmart cost for generic oxybutynin is ~$9 for a supply of 30 generic tablets (GoodRx.com
Your body learns when to release melatonin and cortisol, making it easier to fall asleep at night and wake feeling rested in the morning
Patient symptomatically better and shifted to the ward for further management
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