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In targeted therapy, GSH depletion prevents redox-driven adaptive resistance to PI3K/AKT/mTOR, MAPK, and KRAS inhibitors, intensifying oxidative stress and restoring drug sensitivity
Here, we briefly summarize the lymphatic system in health and disease and the varying mechanisms of lymphatic entry and transport, as well as discussing examples of lymphatic delivery that have enhanced therapeutic utility
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A lower ratio suggests impaired antioxidant defenses, which can lead to lipid peroxidation, protein oxidation, and DNA damage, ultimately promoting apoptosis [103]
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