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However, unlike the relatively predictable conversion from MCI to AD, the progression from hyposmia or rapid eye movement sleep behavior disorder to PD is variable [107], complicating the assessment of GLP-1RAs efficacy in preventing phenotype conversion

Unlike sulfonylureas, which stimulate insulin secretion independently of blood glucose and can lead to hypoglycemia, GLP-1RAs improve glycemic control in a glucose-dependent manner, thereby minimizing the risk of hypoglycemia

The availability of multiple treatment options is leading to profound changes in drug therapy of type 2 diabetes