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But the reality involves a complex chain of immune events that begins long before any symptom appears

Lee: GLP-1 agonists primarily affect the gastrointestinal system, but they also act on the brain, particularly the hypothalamus, which regulates many core functions, including hormones, temperature, and appetite

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This is a serious problem for several reasons: Muscle loss slows your resting metabolic rate, making it harder to keep weight off after stopping the medication Reduced muscle mass increases the risk of falls, fractures, and loss of physical function particularly in older adults The skinny fat phenomenon normal BMI but high body fat percentage is a real outcome of poorly managed GLP-1 use The solution is not to avoid GLP-1 medications