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Here too there are several mechanisms in effect simultaneously: B12 is a strong antioxidant that has proven almost as potent as superoxide dismutase (oxidative stress) (68) B12 is a scavenger of nitrogen radicals and also controls their production (nitrosative stress) (69, 70) B12 plays a role in the creation of glutathione , a central antioxidant (71) Through all of these mechanisms, vitamin B12 plays an important regulating role in all inflammatory diseases and in this way, protects the health of the nerves
The authors also noted that further optimisation was needed, including work relating to high clearance in mice and off-target activity against monoamine oxidase A
Cell culture studies In laboratory studies using 3T3-L1 adipocytes, a commonly used fat cell line, researchers found that 5-amino-1mq significantly reduced intracellular levels of 1-methylnicotinamide, confirming that it was successfully inhibiting NNMT
Studies of radiolabelled cobalamin in cats have demonstrated that the half-life of this compound is significantly reduced in cats with gastrointestinal disease
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