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Evidence strongly supports the heritability of depression, with twin studies estimating heritability at approximately 3750% [297, 298]
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As previously discussed, neurodegenerative and autoimmune disorders such as AD, MS, and PD are associated with reduced GSH concentrations in the brain making supplemental GSH an attractive therapy if the limitations in delivery can be overcome (Smeyne and Smeyne, 2013)
To generate sufficient quantities of ROS and RNS quickly, these cells require rapid flux through the PPP to produce sufficient amounts of NADPH to enable superoxide formation from oxygen by the action of NADPH oxidase (NOX), and nitric oxide (NO) formation from arginine by inducible nitric oxide synthase (iNOS) ( Figure 1A-2 )
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