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The glucagon receptor activation at this dose level also increases resting heart rate by up to 6.7 beats per minute and may trigger dysesthesia (tingling or burning skin sensations) reported in 8.8% to 20.9% of participants at higher doses in Phase 3 trials
In head and neck squamous cell carcinoma, Gln levels increase following radiotherapy, and the Gln transporter SLC1A5 is upregulated
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