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Unlike endogenous -MSH, which degrades within seconds via enzymatic cleavage, MT-1's modified structure resists degradation by serum proteases, allowing sustained melanocortin receptor activation across multiple tissue types

Diabetes: Oxidative stress due to low glutathione can worsen insulin resistance and contribute to the complications of diabetes such as nerve damage and cardiovascular issues

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High dose ( 0.5 mg/kg/d) or long-term use may lead to hypoglycemia, especially in patients with diabetes or insulin resistance