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This uncertainty is the core reason systemic use cannot be considered well characterized

(2021) in a randomized, triple-blind, placebo-controlled study evaluated the efficacy of freshwater marine collagen for 12 weeks on skin attributes in women 4560 years of age in Canada [36]

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In addition, IHC analysis revealed that the P-gp, LC3B, VDAC1, and Ki-67 levels were highest in the HGC-27R-EVs-shNC and HGC-27R-EVs-shNC/PTX groups with no significant difference, suggesting that the transmission of PTX resistance by EV-derived VDAC1 protein through autophagy led to a reduction in the sensitivity of GC cells to PTX ( Figures 6D and S3C )