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Exenatide had 53% homology with GLP-1, had strong binding ability with GLP-1 receptor and was not easily degraded by DPP-4
It is best known for its ability to speed up recovery, reduce inflammation, and improve overall physical function
The "central plan" of GLP-1 RA is not limited to individual cells, but also achieves the reconstruction of whole-body energy metabolism through the neuroendocrine immune network: GLP-1 receptors are highly expressed in areas such as the hypothalamus and solitary tract nucleus of the brain, and their activation can inhibit the activity of appetite centers (such as NPY/AgRP neurons), while enhancing the transmission of satiety signals (such as POMC neurons)
In previous generations of GLP-1 drugs, liver fat was reduced indirectly through weight loss
