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Blood-brain barrier dysfunction in ischemic stroke: targeting tight junctions and transporters for vascular protection
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individual participant data from CANVAS and CREDENCE, which were used to model survival, are available in the public domain through the Yale University Open Data Access Project ( CANVAS and CREDENCE CANVAS and CREDENCE were randomized, double-blind, placebo-controlled, event-driven trials evaluating the effects of the SGLT2i canagliflozin on cardiovascular, kidney, and safety outcomes in 14 543 participants with type 2 diabetes at high cardiovascular risk (CANVAS) or with albuminuric CKD (CREDENCE)
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